The primary mechanism of photo skin aging is mediated by UV induced reactive oxygen species (ROS). ROS damages biomacromolecules and function as intracellular signal to activate transcription factors AP-1 and NF-kB . AP-1 And NF-kB are known to regulate a … Continue reading
The primary mechanism of UV-induced skin aging is mediated by the generation and accumulation of free radicals including reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS or free radicals not only can damage proteins, DNA, cellular membrane and … Continue reading
Mitochondria are cellular organelles that produce energy (ATP) by consuming oxygen. In the chronological aging process, mitochondria not only produce less ATP, but they also increase the production of reactive oxygen species (ROS) as by-products of aerobic metabolism, particularly during … Continue reading