ReVive’s Peau Magnifique Youth Recruit is the most costly stem cell cream on the market ($1500 a month supply). The company insists that the high cost is because of an enzyme ingredient in the product – telomerase which is a bio-engineered protein costing about $4 million/gram. ReVive Peau Magnifique Youth Recruit’s effectiveness is due to telomerase.

Telomerase is an enzyme which adds DNA sequence repeats “TTAGGG” to the 3′ end of DNA strands in the telomere regions at the ends of chromosomes. This region of repeated nucleotide called telomeres contains noncoding DNA and functions to prevent the loss of important DNA from chromosome ends. As a result, every time the chromosome is copied only 100–200 nucleotides are lost, which causes no damage to the organism’s DNA. Telomerase activity and telomere length was found to be associated with cellular senescence. Very few somatic cell types express sufficient quantity of telomerase to overcome the Hayflick limit to proliferation. However, embryonic stem cells are found to have the high expression of telomerase. This overexpression of telomerase permit embryonic stem cells to escape senescence. Exogenous bio-engineered telomerase has been adopted as a means to immortalize cells.

When applied topically, it can also create a signal cascade to skin stem cells, resulting in stem cell’s reaction as they would to an tissue injury including the release of EGF. Epidermal Growth Factor (EGF), a protein found naturally in the human body that is released from the cells after injury to increase cell turnover, enhances regeneration of aging skin.

ReVive’s Peau Magnifique Youth Recruit does not add or inject stem cells into the skin. It merely stimulates and accelerates existing stem cell’s ability to promote skin cell’s natural rejuvenation process. It convert resting adult stem cells to new skin cells. Besides telomerase, ReVive’s Peau Magnifique Youth Recruit is a mixture of many other anti-aging ingredients including RES Technology, Bio-3 Cell Renewal Complex.