Mechanism of UV Induced ROS Generation: Photosensitization

The primary mechanism of UV induced skin aging is the production and generation of reactive oxygen species (ROS). ROS/free radicals is one of the main causes of chronologic and photo skin aging. ROS damages and oxidizes biomacromolecules and cellular components. … Continue reading

The Effect of UV-Induced Gene Activation On Photo Skin Aging

The primary mechanism of UV-induced skin aging is mediated by the generation and accumulation of free radicals including reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS or free radicals not only can damage proteins, DNA, cellular membrane and … Continue reading

Mechanism of UV Induced ROS Generation: NADPH Oxidase Activation

The primary mechanism of UV induced skin aging is the production and generation of reactive oxygen species (ROS). ROS/free radicals is one of the main causes of chronologic and photo skin aging . ROS exerts aging effect via damaging and … Continue reading

ROS and UV Induced Mitochondria DNA Mutation and Common Deletion In Skin

Mitochondria are cellular organelles that produce energy (ATP) by consuming oxygen. In the chronological aging process, mitochondria not only produce less ATP, but they also increase the production of reactive oxygen species (ROS) as by-products of aerobic metabolism, particularly during … Continue reading

NF-kB and AP-1 Molecular Signaling Mechanisms of Intrinsic And Extrinsic Skin Aging

The molecular signaling pathways associated with skin aging is most and initially studied in the photo skin aging. Numerous researches published combined the pieces of discovery into an general overview picture about what occurred molecularly in photo skin aging. It … Continue reading

The Antioxidant Enzymes Network of The Skin

The physiological cellular respiration located at mitochondria is always comes with the byproduct of the aerobic metabolism where a small fraction of the oxygen is constantly converted to superoxide anions, hydrogen peroxide, hydroxyl radicals, and other ROS. Although within a … Continue reading