Anti-Aging Peptide Ingredients
– SYN®-AKE (Tripeptide)
SYN®-AKE is an effective anti-wrinkle compound based on a synthetic tripeptide that mimics the effect of Waglerin 1, a peptide found in the venom of the Temple Viper, Tropidolaemus wagleri (snake venom). SYN®-AKE helps to smoothen expression lines and to relax your face. SYN®-AKE won the well reputed and highly coveted Swiss Technology Award in 2006. SYN®-AKE’s INCI name is: Glycerin, Water, Dipeptide Diaminobutyroyl Benzylamide Diacetate
The Temple Viper’s hunting method makes use of the venom protein Waglerin 1, which has a strong muscle relaxing effect. The tripeptide SYN®-AKE mimics the essential amino acid sequence of this functionality. SYN®-AKE‘s activity is attenuated compared to Waglerin 1 and has been thoroughly tested. It is a safe, effective, and painless alternative to controversially discussed muscle relaxing anti-aging treatments like botulinum toxin in Botox injectable filler. (Literature McArdle, JJ, T L Lentz, V Witzemann, H Schwarz, SA Weinstein & JJ Schmidt. 1999. Waglerin-1 selectively blocks the epsilon form of the muscle nicotinic acetylcholine receptor. J. Pharmacol. Exp. Therap. 289:543-550.)
SYN®-AKE’s mode of action is similar to that of Waglerin 1 which acts at the postsynaptic membrane. The peptide is an antagonist of the muscular nicotinic acetylcholine membrane’s receptor (mnAChR). As the muscular nicotinic ACh receptors are blocked, the nerve signal can not be transmitted and the muscles stay relaxed.
According to Pentapharm official web site, SYN®-AKE is fast acting. suggested concentration is 1–4% SYN®-AKE. The efficacy of the SYN®-AKE tripeptide (0.5 mM) has been demonstrated in vitro by measuring the frequency of contraction of the innervated muscle cells as a function of the incubation time. SYN®-AKE peptide reduces muscle cell contraction and its action is reversible. In vivo clinical study was performed on 15 volunteers per group (age 40–60). The measurement of the smoothing and anti-wrinkle effect of SYN®-AKE (4%) was compared to a placebo. A cream was applied to the forehead twice daily for 28 days. The smoothing effect was measured on 80% of the volunteers and the anti-wrinkle effect measured on 73% of the volunteers. Results showed up to 52% reduction of wrinkle size after 28 days application.