How Ground Substance Contribute To The Manifestations of Aging Skin

The ground substance occupies the space between the cells and fibers of dermal connective tissues. It is an amorphous viscoelastic gel in which the other components (cells and fibers) are held in place . Ground substance consists largely of proteoglycans … Continue reading

Age-Related Changes in The Proteoglycans of Skin

The dermis of skin is a connective tissue that contains an extensive extracellular matrix (ECM) whose biophysical properties are determined primarily by this matrix. Although collagen and elastin are the major extracellular matrix molecules of the dermis that provide skin … Continue reading